Filamentous actinobacteria are widely used as microbial cell factories to produce valuable secondary metabolites, including the vast majority of clinically relevant antimicrobial compounds.Secondary metabolites are typically encoded by large biosynthetic gene clusters, which allow for a modular approach to generating diverse Contours compounds thro
Abstract The endoplasmic reticulum (ER) and mitochondria are interconnected intracellular organelles with vital roles in the regulation of cell signaling and function.While the ER participates in a number of biological processes Belts including lipid biosynthesis, Ca2+ storage and protein folding and processing, mitochondria are highly dynamic orga
Despite the induction of effective immune responses, 80% of hepatitis C virus (HCV)-infected individuals progress from acute to chronic hepatitis.In contrast to the cellular immune response, the role of the humoral immune response in HCV clearance is still subject to debate.Indeed, HCV escapes neutralizing antibodies in chronically infected patient
As an inhibitor of microtubule assembly, combretastatin A-4 (CA-4)-induced biological responses in tumor cells have been well known, but the corresponding changes in Body Massage Tool nano-biophysical properties were not investigated given the lack of an ideal tool.Using AFM technique, we investigated the alteration of nano-biophysical properties w